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Common genetic variants can prevent antibody therapies from binding their targets, reducing treatment effectiveness. The study shows how small amino acid changes can block drug binding.

A study of 341 FDA trials conducted between 2017 and 2023 found that only 6% reflected US racial demographics, with declining participation among Black and Hispanic patients.

Nagoya University researchers discovered a gene that actively suppresses food-odor detection in roundworms after reproduction ends. The finding challenges the idea that aging is purely due to accumulated damage.

SickKids researchers discovered that a long non-coding RNA, CISTR-ACT, directly regulates cell size. Using gene-editing tools, they showed that increasing CISTR-ACT shrinks cells, while removing it makes cells larger.

Penn State researchers discovered that two proteins within the CCR4-NOT complex have opposing effects on mRNA stability. Using a precision protein-degradation tool in human cancer cells, the team showed that one protein slows mRNA decay.

University of Pittsburgh researchers identified changes in BDNF DNA methylation as a dynamic biomarker of complicated pediatric traumatic brain injury. Blood samples showed reduced methylation during early recovery that normalized by one year.

Researchers reconstructed the genetic and social structure of a Protoapennine community from Bronze Age Italy using ancient DNA. The study reveals kinship patterns, long-distance mobility and cultural practices, including dairy consumption.

Scientists at EPFL have discovered a molecular early-warning system that protects cells from excessive lipid oxidation and ferroptosis, a regulated form of cell death linked to aging and many diseases.

Researchers identified genetic variants in two lung-related proteins that alter the risk of retinopathy of prematurity. Some variants increased risk, while others were protective, acting opposite to their effects in the lungs.

A new study reveals that tanning beds cause melanoma-linked DNA damage across almost the entire skin surface, explaining the nearly threefold rise in melanoma risk seen in users. Single-cell sequencing showed widespread mutations.