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Analysis & Separations

Analysis & Separations

Featured Articles

3D illustration of an RNA strand on a gradient background, representing RNA therapeutics research.

Addressing Development Challenges for RNA Therapeutics

This article explores how challenges such as sequence optimization, immune activation and off-target effects are being addressed to enhance the safety, durability and efficacy of RNA therapeutics.

Illustration of CAR T-cell therapy targeting a cancer cell, highlighted by a crosshair overlay.

Improving the Efficacy and Accessibility of CAR Therapies

In this interview, Dr. Neil Sheppard, director of the Therapeutic Innovation in Natural Killer cells (THINK) lab at the University of Pennsylvania, discusses the challenges involved in developing new CAR-based treatments.

3D illustration of an atom structure used to visualize atomic analysis in X-ray spectroscopy.

X-Ray Spectroscopy

Explore the world of X-ray spectroscopy, a key tool for unveiling atomic structures and elemental compositions across diverse fields.

Latest Articles

Modern LC-MS/MS mass spectrometer in a proteomics laboratory with monitors displaying mass spectral data and chromatograms.

Mass Spectrometry for Proteomics: Techniques, Tools and Tips

Master mass spectrometry for proteomics with this guide on techniques like LC-MS/MS, MALDI, and DIA vs DDA to enhance laboratory workflows and data.

Digital human figure dissolving into colored data blocks, symbolizing spatial biology and cellular mapping.

Spatial Biology: A New Frontier in Understanding Biological Systems

This article explores how researchers are using spatially resolved methods to explore diverse biological processes from development and tumorigenesis to fibrosis, neurodegeneration, infection and inflammation.

Visual representation of molecular profiling with DNA and a human figure.

Proteomics vs Genomics: Key Differences in Molecular Profiling

Comparing proteomics to genomics reveals essential insights into their contributions to systems biology and experimental design. Learn how the different omics layers advances molecular profiling.

A collection of hexagons with "AI" and other digital-like icons written in them, hovering over a person's outstretched palm.

The Future of AI/ML in Liquid Chromatography

AI and ML are changing chromatography. Hear from an expert about the hype, the challenges and the opportunities seen today.

High-resolution mass spectrometer visualizing complex proteomics data transformation.

Navigating the Proteome: A Comprehensive Proteomics Glossary for Researchers

A definitive guide to proteomics definitions, mass spectrometry terminology, and key concepts in quantitative proteomics for life science researchers and lab scientists.

Abstract scientific visualization illustrating middle-down proteomics bridging the gap.

Middle-Down Proteomics: Bridging Bottom-Up and Top-Down

Middle-down proteomics addresses the limitations of conventional bottom-up approaches by providing deeper insight into proteoform analysis.

Dynamic, abstract depiction of top-down proteomics.

Top-Down Proteomics Explained: Advantages and Challenges in Intact Protein Analysis

A detailed examination of top-down proteomics and its critical role in comprehensive proteoform identification using advanced mass spectrometry techniques.

Abstract visualization of bottom-up proteomics, showing proteins fragmenting into peptides within a mass spectrometer.

Deconvoluting the Proteome: Principles and Advances in Bottom-Up Proteomics

A comprehensive overview of bottom-up proteomics, detailing the critical stages from protein digestion and peptide analysis to mass spectrometry detection.

Abstract proteomics workflow visualization: sample prep to data analysis. SEO Description: A vibrant, abstract digital illustration depicting the full proteomics workflow, from initial sample preparation and LC-MS analysis to advanced bioinformatics and data interpretation. Ideal for scientific publications and educational content.

Navigating the Modern Proteomics Workflow: Key Technical Considerations

Optimize the proteomics pipeline: critical sample preparation, LC-MS workflow, and advanced data processing.

Complex 3D rendering of protein structures illustrating molecular interactions in proteomics.

Protein Shape Changes Could Reveal Early Disease Signals

At HUPO 2025, ETH Zurich’s Prof. Paola Picotti discussed how limited proteolysis mass spectrometry tracks protein shape changes rather than abundance alone. She highlighted how metabolite–protein interaction mapping can reveal functional shifts.

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