LipidLaunch™: Lipid Nanoparticle Research Tools for RNA Therapies

Cayman's LipidLaunch™ research-ready LNPs, reagent kits, and screening sets help researchers pursue lipid nanoparticles (LNPs) for the delivery of nucleic acid therapies. LipidLaunch™ Research Tools aim to simplify LNP research by providing accessible and cost-effective solutions for researchers at all stages of their work. These research-ready LNPs and reagent kits utilize lipid formulations of broad and current interest, such as those used in mRNA-based vaccines or cell and gene therapies. Available in various formats, they offer researchers flexibility in cargo selection and LNP formulation. From Discovery to Bioanalysis, Explore Tailored LipidLaunch™ Solutions: LipidLaunch™ Preloaded LNPs: Preformulated LNPs containing reporter gene mRNA, ideal for initial pilot or proof-of-concept experiments. • Ideal for LNP screening • Features reporter readout • First choice for pilot studies and novice researchers LipidLaunch™ Loadable LNPs: Cargo-ready, preformulated LNPs that allow researchers to deliver their chosen RNA cargo. • Ideal for LNP screening • Custom cargo compatible • Preferred option for custom cargo and maximum ease-of-use LipidLaunch™ LNP Exploration Kits: Complete kits with individually packaged reagents for creating customized LNPs without specialized equipment. • Ideal for LNP screening • Custom cargo compatible • Customizable LNP formulation • Top choice for preparing LNPs with custom cargo and formulation LipidLaunch™ LNP Uptake Kits: Built on the Exploration Kit format, these kits include a fluorescently labeled lipid for visualizing LNP cellular uptake. • Features reporter readout • Custom cargo compatible • Customizable LNP formulation • Ideal for visualizing cellular uptake with custom LNPs LipidLaunch™ LNP Screening Sets: Curated sets of individual lipids for use in LNP formulations or screening and optimization based on current interests in LNP research, including achieving targeted delivery of the nucleic acid cargo. • Lung- and T cell-targeting ionizable cationic lipids • Broad ionizable lipids • Helper lipids • Cholesterol analogs • Phospholipids LNPs are customizable platforms built from lipids used for the delivery of nucleic acid therapies. Because of their versatility, LNPs are a promising strategy for many therapeutic approaches from vaccine development to cancer and cell or gene therapies. Designed with researcher accessibility in mind, Cayman’s LipidLaunch™ research-ready solutions support the entire LNP research and development process from discovery to bioanalysis. Designed with researcher accessibility in mind, LipidLaunch™ research tools require minimal hands-on time and expertise. Preloaded and Loadable LNPs eliminate the need for expensive and complex mixing steps, ensuring ease of use. The Exploration and Uptake Kits allow for LNP preparation using simple hand mixing techniques or, if available, microfluidic mixers.