Latest App Notes & Case Studies

This app note highlights an optimized HILIC-MS/MS approach that significantly enhances signal strength for GalSPH and GluSPH analysis in CSF.

This app note highlights an optimized microflow LC-MS/MS approach that significantly enhances signal strength for biomarker quantitation in laser microdissected brain tissue.

This app note highlights an optimized system for assessing mitochondrial respiration and glycolysis in brain tissue slices. It introduces a workflow that enables real-time, high-sensitivity metabolic profiling with consistent, reproducible results.

This application note explores how an advanced 5 L single-use bioreactor enhances productivity, reduces costs and enables seamless scalability from bench to production.

This case study shows how a next-generation pTau 217 assay achieves higher accuracy than existing platforms using only 1 µL of diluted plasma, while maintaining robust performance across freeze-thawed samples and diverse cohorts.

This application note highlights a mature 3D organoid model that combines cerebral organoids with tau preformed fibrils to support mechanistic research and therapeutic screening in a human-relevant setting.

This application note demonstrates how an automated parallel CE-SDS system can provide reliable measurements from 1 µL of protein crude lysate in just 30 minutes.

This article reviews pathological and physiological role of Tau proteins in neurodegeneration, Tau-targeted drug development strategies, and SignalChem’s contribution

This application focus explores how IMC can be applied to identify major cell populations that make up mouse brain matter.

This application note demonstrates how imaging mass cytometry (IMC) is transforming neurodegeneration research, providing detailed visualization of protein aggregates, neuron populations and inflammatory cell interactions.