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Fischer glycosidation appeared an ideal candidate for the application of microwave irradiation and herein we report a systematic analysis of the effect of microwave heating in the Fischer glycosidation reaction.

The drive towards miniaturization within the pharmaceutical and biotechnology fields has created a need for liquid handling technologies that accurately deliver low volume reagents to high-density plates. This has also created a need for simple, fully scaleable assays in low volumes. Here we demonstrate the successful combination of both through the use of the Equator™ NS 808 - Eight Tip Pipetting System and the dual color Chroma-Luc™ technology.

CX3CR1 has been stably transfected into CHOmitoPhotina™- MRE-CRE-Luciferase cell line and assays suitable for HTS and uHTS have been developed.

This study describes the generation of a cell based assay which allows the functional characterization of the human GPVI receptor, by the use ofluminescence.

Using the Muscarinic M1 G-protein Coupled Receptor as a model system, we achieved accurate and reproducible determinations of binding affinity (Kd) and IC50 results for known ligands on the 384-well plate device. As a result of being able to incubate the reaction mixture in the filter plate and configure the assay using half the reaction volume, significant reductions in reagent costs and radioactive waste were achieved.

We screen natural products for antimicrobial, antiviral and anticancer activity, immunomodulatory effects, as inhibitors of cell adhesion and antioxidants. High resolution MRI-tomography with 7T magnet (PharmaScan 70/16US, Bruker) allows us to search in situ for compounds with anticancer, anti stroke and anti ischemia activity, inhibitors of angiogenesis and hepatoprotective substances.