News

Researchers transplanted a single-edit α-Gal knockout pig kidney and thymus into a brain-dead recipient, followed by 61 days of monitoring. The organ produced urine, maintained electrolyte balance and withstood antibody-mediated rejection.

Researchers show that chronic growth hormone excess drives liver aging by boosting glycation stress and inflammation. Mice engineered to overproduce GH developed liver changes mirroring natural aging, but lowering glycation reversed many effects.

A new study shows that the U.S. Preventive Services Task Force screening criteria for lung cancer exclude at-risk patients.

Cedars-Sinai researchers found that senescent blood vessel cells drive inflammation and metabolic dysfunction in obesity. Removing these cells or treating mice with the senolytic fisetin reduced inflammation, fat mass and blood sugar levels.

A large proteomics study of 3,707 Greenlanders identified 251 genetic variants that strongly affect inflammation- and cardiovascular-related proteins. Many variants, enriched by Arctic adaptation, exert far stronger effects than in Europeans.

A study of 84,000 people shows that nearly 90% of individuals with familial hypercholesterolemia would be missed by current screening guidelines. DNA testing revealed 419 carriers, many unaware of their risk and some already with heart disease.

A new patch developed by Texas A&M University researcher Dr. Ke Huang may offer a way to help the heart heal after a heart attack. The patch uses a unique microneedle system to deliver a therapeutic molecule directly to damaged heart tissue.

Automated imaging and machine learning analyze drying biofluid droplets, enabling fast, low-cost disease detection from a single drop.

People affected by childhood trauma have a 50% higher risk of developing a mental health condition later in life, with strong links also found to chronic conditions including cancer and kidney disease.

UK Biobank has released the final metabolomic dataset for 500,000 participants, completing the world’s largest metabolomics resource. Covering nearly 250 blood metabolites, the data enable new insights into disease risk, mechanisms and aging.