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Dynamic Behavior of Unstable Protein Revealed
Explore how the YB1 protein's intrinsic disorder helps it perform crucial cellular functions, impacting cancer therapies.
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Why Important Genes "Go Quiet" as We Get Older
Researchers have uncovered a specific form of epigenetic aging that leads to the shutdown of key genes in intestinal stem cells.
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Mini Lung Organoids Made in Bulk Could Help Test Personalized Cancer Treatments
Discover a simple, automated method of producing many lung organoids at once, open the door for more effective ways to trial lung disease and cancer treatments.
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A Rare Disease That Burns Fat Instead of Sugar
A study using isotope tracing metabolomics found that people with Fanconi anemia fail to use glucose efficiently, show elevated ketones and signs of insulin resistance. The findings reveal metabolic inflexibility.
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Simple Method Automates Manufacturing of Lung Organoids
Automated lung organoid production offers scalable, human-based models for testing therapies and accelerating lung disease research.
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Drug Combination Can Sidestep Neuroblastoma Resistance Mechanisms
New research has identified a drug combination that can bypass the cellular defences of neuroblastoma that lead to relapse.
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CAR-NKT Therapy Overcomes Barriers of Solid Tumors in Pancreatic Cancer Models
UCLA’s CAR-NKT therapy overcomes solid-tumor barriers, eliminating primary and metastatic pancreatic cancer in advanced preclinical models.
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Many Patients May Not Need Long-Term Hormone Therapy for Prostate Cancer
A new study outlines that most of the benefits of hormone therapy for prostate cancer occur in the first 9 to 12 months, and extending therapy increases the risk of health problems.
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Proteins Responsible for Cancer's Shapeshifting Identified
Some cancers can "shapeshift" and start to resemble cells from other organs. New research has identified the proteins involved.
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Rare Mutation Predicts Strong Immunotherapy Response in Colorectal Cancer
A new study shows that a specific subset of mutations in the POLE gene is strongly associated with durable responses to immunotherapy in patients with metastatic colorectal cancer.
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