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Visualization of a protein structure and its molecular backbone.
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Dynamic Behavior of Unstable Protein Revealed

Explore how the YB1 protein's intrinsic disorder helps it perform crucial cellular functions, impacting cancer therapies.
Cells and a coil of DNA, illustrating genetic changes in cells as we age.
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Why Important Genes "Go Quiet" as We Get Older

Researchers have uncovered a specific form of epigenetic aging that leads to the shutdown of key genes in intestinal stem cells.
A plastic anatomical model of a pair of lungs.
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Mini Lung Organoids Made in Bulk Could Help Test Personalized Cancer Treatments

Discover a simple, automated method of producing many lung organoids at once, open the door for more effective ways to trial lung disease and cancer treatments.
A 3D-rendered image of two cancer cells in the process of division.
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A Rare Disease That Burns Fat Instead of Sugar

A study using isotope tracing metabolomics found that people with Fanconi anemia fail to use glucose efficiently, show elevated ketones and signs of insulin resistance. The findings reveal metabolic inflexibility.
Illustration of lungs symbolizing automated bioreactor methods that mass-produce lung organoids for high-throughput disease research.
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Simple Method Automates Manufacturing of Lung Organoids

Automated lung organoid production offers scalable, human-based models for testing therapies and accelerating lung disease research.
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Drug Combination Can Sidestep Neuroblastoma Resistance Mechanisms

New research has identified a drug combination that can bypass the cellular defences of neuroblastoma that lead to relapse.
Fluorescent image of a CAR-NKT immune cell engaging a pancreatic tumor cell, illustrating targeted solid-tumor attack.
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CAR-NKT Therapy Overcomes Barriers of Solid Tumors in Pancreatic Cancer Models

UCLA’s CAR-NKT therapy overcomes solid-tumor barriers, eliminating primary and metastatic pancreatic cancer in advanced preclinical models.
A male patient speaks to a doctor.
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Many Patients May Not Need Long-Term Hormone Therapy for Prostate Cancer

A new study outlines that most of the benefits of hormone therapy for prostate cancer occur in the first 9 to 12 months, and extending therapy increases the risk of health problems.
Cancer cells of different shapes and sizes.
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Proteins Responsible for Cancer's Shapeshifting Identified

Some cancers can "shapeshift" and start to resemble cells from other organs. New research has identified the proteins involved.
Doctor in a lab coat and blue latex gloves with an outstretched hand. The hand appears to be holding futuristic icons representing DNA, sequencing and health information.
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Rare Mutation Predicts Strong Immunotherapy Response in Colorectal Cancer

A new study shows that a specific subset of mutations in the POLE gene is strongly associated with durable responses to immunotherapy in patients with metastatic colorectal cancer.
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