News

A two-year trial of young people taking second-generation antipsychotics found that metformin modestly reduced medication-related weight gain. The effect persisted over 24 months and supports the prescribing of metformin when antipsychotics begin.

Screening gut bacteria against hundreds of FDA-approved drugs revealed that tetracyclines activate hidden metabolic pathways in B. dorei, influencing immune function and potentially reshaping the gut microbiome.

Adding spironolactone to HIV treatment shows promise in accelerating viral decay and reducing inflammation linked to chronic HIV infection.

Researchers developed a method that integrates bulk and single-cell data to map how genetic variants influence gene expression across seven brain cell types. The tool identified about 75% more disease-relevant genes than conventional approaches.

Researchers developed Bits2Bonds, a platform that merges molecular dynamics simulations with machine learning to design new polymer materials for RNA delivery. The tool enables rapid virtual screening of thousands of candidates before lab testing.

Using cryo-electron microscopy, researchers have visualized how widely used epilepsy drugs bind and reshape the neuronal protein SV2A, uncovering an additional binding site that could enable more potent and precise therapies.

New research indicates that clinical use of nitrous oxide could offer fast-acting symptom relief for treatment-resistant and major depression.

HIIT safely improves aerobic capacity and muscle endurance in newly diagnosed inflammatory muscle disease patients.

New research has identified a drug combination that can bypass the cellular defences of neuroblastoma that lead to relapse.

A new discovery about brain receptors that control the breakdown of amyloid beta may open the door to new Alzheimer’s treatments.