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Three to Four Cups of Coffee Linked to Slower Cellular Aging
A study of 436 adults with severe mental illness found that drinking three to four cups of coffee a day was associated with longer telomeres, equivalent to a biological age around five years younger than non-drinkers.
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Mutations Cluster at Gene Start Sites – And We’ve Been Missing Them
A genomic analysis shows that transcription start sites are 35% more mutation-prone than expected, making them one of the genome’s most vulnerable regions. Many of these errors arise as mosaic mutations during early embryonic cell divisions.
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Hotter Weather Leaves a Molecular “Fingerprint” in Pregnant Mothers
An Emory University study of 215 pregnant women provides the first biological evidence connecting heat exposure to preterm birth. Metabolomic profiling showed that hotter temperatures disrupt key stress- and energy-related molecules.
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Blood Protein Profiles Could Help Predict Mortality
Large-scale profiling links specific blood proteins to 5 and 10-year mortality risk, offering potential tools for early clinical intervention.
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Over Half of the American Population Is Affected by a Neurological Disease or Disorder
A new analysis shows that 54% of the US population is affected by a medical condition that affects nervous system health, including migraine, diabetic neuropathy and stroke.
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The Genetics of Impulsive Choices: What 134,000 Genomes Reveal
UC San Diego researchers identified 11 genetic regions tied to delay discounting, preferring smaller immediate rewards over larger delayed ones. These genes overlap with pathways involved in cognition, dopamine signaling and metabolism.
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Rare Mutation Predicts Strong Immunotherapy Response in Colorectal Cancer
A new study shows that a specific subset of mutations in the POLE gene is strongly associated with durable responses to immunotherapy in patients with metastatic colorectal cancer.
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Cutting Ultra-Processed Foods Triggered Weight and Insulin Improvements
A controlled feeding trial found that older adults who cut ultra-processed foods automatically consumed fewer calories, lost total and abdominal fat and improved insulin sensitivity. Both plant- and animal-protein diets showed similar benefits.
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The Brain on DMT: Why Your Inner Narrative Falls Away
A new EEG analysis shows that DMT reduces structure in theta, alpha and beta brainwaves, shifting neural activity away from its usual balance between order and randomness. Larger disruptions were tracked with stronger reports of ego death.
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