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New Stem Cell Medium Only Has Canine Components
A research team has made a stem cell medium that doesn't contain any human components. E. coli was used to introduce canine proteins into the medium to act as a scaffold for the stem cells.
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Biologists Can Now Tune Proteins in Specific Tissues for the First Time
Researchers developed a dual-channel AID system that allows precise, lifelong tuning of protein levels in specific tissues of C. elegans. The method overcomes major limits of traditional on/off genetic tools.
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CAR T Cells Shown To Rejuvenate the Aging Gut
Targeting senescent cells with CAR T therapy restores gut epithelial renewal and protects against radiation-induced damage, offering a potential path to improve gut health in older adults and cancer patients.
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Ebola and Marburg Viruses Shown to Infect Human Gut Cells
Scientists found that Ebola and Marburg viruses replicate in human gut organoids and interfere with fluid and barrier functions, with particularly severe effects in colon-like tissue.
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Ferroptosis Mechanism Offers New Route for Psoriasis Therapy
Psoriasis involves immune dysregulation and a lipid-driven mechanism in which FABP5 induces ferroptosis. Blocking FABP5 eases inflammation, pointing to a potential new treatment pathway beyond current treatments.
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Molecular Movie Captures How a Mitochondrial Enzyme Processes RNA
Researchers have captured the first detailed molecular snapshots of human polynucleotide phosphorylase (hPNPase) in action, revealing how this essential mitochondrial enzyme degrades RNA through an elegant base-flipping mechanism.
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Membrane "Neighborhood" Helps Transporter Protein Regulate Cell Signaling
Scientists at St. Jude Children’s Research Hospital identified a protein network which locks ABCC4 transporters in place to maintain cyclic AMP signaling levels.
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AI Tool Reveals How Genes Team Up To Drive Cancer
University of South Australia researchers developed an AI-based framework that uncovers how groups of genes work together to drive cancer progression. Tested in breast cancer datasets, the method identified known cancer drivers.
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How Microtubules Take Part in Cellular Signal Processing
Microtubules perform an active role in communication within the cell by transmitting received signals to the cell's functional units. Researchers have now structurally elucidated how these protein strands of the cytoskeleton accomplish this.
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Astrocyte Diversity Across Space and Time Mapped
Researchers have created an atlas detailing the dynamic diversity of astrocytes over space and time.
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