News

Researchers have discovered a key mechanism that makes prostate cancer cells resistant to the latest drugs, solving a long-standing puzzle in tumor biology.

University of South Australia researchers developed an AI-based framework that uncovers how groups of genes work together to drive cancer progression. Tested in breast cancer datasets, the method identified known cancer drivers.

As they develop, pancreatic cancer cells express the genes that will determine where they metastasize.

A Mount Sinai team showed that the same leukemia mutation behaves differently depending on when it arises during development. Using CRISPR in human blood stem cells, they found prenatal-origin leukemias are more aggressive and treatment-resistant.

A novel computational tool has been used to identify a metabolic weakness in acute myeloid leukemia, offering a new drug target.

Researchers at St. Jude built a machine learning model to predict which protein regions drive cancer-linked condensates. Testing intrinsically disordered regions from fusion oncoproteins, they found only 12% of human regions form droplets.

Researchers used CRISPR screening in tumor organoids and mice to identify two genes, Ctnna1 and Bcl2l13, that suppress colorectal cancer metastasis. One limits cell invasion, while the other triggers cell death after detachment.

A Karolinska Institutet study of nearly 400 patients shows that a lower dose of ipilimumab in combination immunotherapy for advanced melanoma leads to better tumor response, longer survival and fewer side effects compared to the traditional regimen.

Researchers have characterised the structure and function of a key protein that helps breast cancer cells survive.

Biotech and pharma greenhouse gas emissions are falling – but is current progress fast enough? Discover My Green Lab’s Impact Report.