Latest App Notes & Case Studies
App Note / Case Study
Extended Analysis of mAbs Using Ion-Exchange Chromatography on the Alliance™ iS Bio HPLC System
In this study an Alliance iS Bio HPLC System is employed in a 30-day robustness test using a salt gradient IEX method.
App Note / Case Study
Monitoring Impurities Using a High Throughput Focused Gradient With the Alliance™ iS Bio System
In this study, a shortened focused gradient targeting an oxidized peptide and its native species was developed via mass confirmation and transferred to the Alliance iS Bio HPLC System which provides high throughput and efficient monitoring.
App Note / Case Study
Evaluation of Modern and Legacy HPLC Systems for the Size-Exclusion Analysis of Aggregation and Fragmentation in a Monoclonal Antibody Drug
In this work an Alliance iS Bio HPLC System, an Alliance e2695, and a competitive Bio-inert HPLC system are compared using a size-exclusion method for analysis of monoclonal antibody aggregation and fragmentation.
App Note / Case Study
Successful Method Migration of USP Insulin Assay to the Alliance™ iS Bio HPLC System
In this work, the USP Monograph for Insulin Assay will be tested across multiple systems, evaluating both system suitability requirements and % API potency of the substance, USP Human Insulin RS.
App Note / Case Study
Evaluation of System Robustness of the Alliance™ iS Bio System Using Peptide Mapping Analysis
In this study, the Alliance iS Bio HPLC System is evaluated for robustness over a period of 30 days using a long, shallow gradient peptide mapping method.
App Note / Case Study
Advancing Charge Variant Analysis With pH-Gradient Ion-Exchange Chromatography: Optimizing Monoclonal Antibody Characterization Using the High-pH Kit for the Alliance™ iS Bio HPLC System
The study establishes a robust, sensitive, and reproducible method, ensuring confidence in charge variant characterization for therapeutic mAbs.
App Note / Case Study
Alliance iS HPLC System: A New Era of Intuitive Simplicity
Specific use cases of the Waters Alliance iS HPLC System include common pharmaceutical QC applications, the analysis of soft drink additives, replicating HPLC methods for water-soluble vitamins, and method migration from legacy HPLC systems.
App Note / Case Study
HPLC Autosampler Performance II: Improved Injection Precision of USP Methods With the Alliance™ iS HPLC System
The injection precision performance of the Alliance iS HPLC System and similar HPLC systems were compared using four compendial HPLC methods from the United States Pharmacopeia (USP). (Part 2 of 2)
App Note / Case Study
HPLC Autosampler Performance I: Challenging USP Methods on the Alliance™ iS HPLC System
The injection precision performance of the Alliance iS HPLC System and similar HPLC systems were compared using four compendial HPLC methods from the United States Pharmacopeia (USP). (Part 1 of 2)
App Note / Case Study
Improved Sensitivity for Trifluoroacetic Acid Gradients on the Alliance™ iS HPLC Systems
While testing the monograph on the Alliance™ iS Bio HPLC System and Alliance iS HPLC System, we observed improved sensitivity with the diffusion bonded mixer, as well as the impact of instrument settings
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